Testosterone replacement therapy (TRT) has become increasingly popular for men experiencing symptoms of low testosterone (low T). While TRT can offer many benefits, some individuals worry about side effects. One that often comes up is headaches. 

Let’s explore the potential connection between testosterone and headaches, addressing key questions like “can TRT cause headaches?” and “does low testosterone cause headaches?”

What is TRT?

TRT is a medical treatment designed to restore healthy testosterone levels in men with low T. This therapy can be administered through various methods, including injections, patches, gels, and implants. Symptoms of low testosterone can include fatigue, depression, and decreased libido. By undergoing TRT, men can often alleviate these symptoms and improve their overall quality of life. 

The main benefits to TRT include: 

  • Increased energy levels 
  • Improved mood 
  • Enhanced libido
  • Increased muscle mass and bone density
  • Better cognitive function

Despite the numerous benefits, however, understandably, there is often concern with possible side effects. 

Can Testosterone Cause Headaches?

One of the common concerns raised by patients undergoing TRT is whether it’s normal to get headaches from testosterone injections. While there isn’t a definitive answer to “does testosterone cause headaches?” some evidence suggests that hormone fluctuations may play a role in headache development. Some other factors that could lead to potential headaches as a result of TRT are increased blood pressure, dehydration, and sleep disruption. It’s important to monitor any new symptoms after starting TRT and discuss them with a healthcare provider.

“I see no relationship between using testosterone, what testosterone can be turned into, or anything like that that would cause a headache,” says Dr. Rand McClain of the Regenerative and Sports Medicine clinic. “If you came to me and said this is what’s happening I would say you need to go follow up with a physician because no, that’s not normal.” 

man with a headache wondering if it is from testosterone replacement therapy

Can Low Testosterone Cause Headaches?

While TRT should not cause headaches, there is research that says having low testosterone could lead to developing headaches, and even migraines.

The relationship between migraines and testosterone is complex. Some studies suggest that hormone levels can influence migraine frequency and intensity. For instance, low testosterone headaches might be linked to hormonal imbalances that exacerbate migraine conditions. On the other hand, testosterone for migraines has been considered in certain cases, indicating a potential therapeutic role for hormone therapy in managing migraine symptoms.

Men with low T often wonder, “can low T cause headaches?” The answer appears to be yes. Headaches because of low testosterone is a documented phenomenon, with many patients reporting a low testosterone headache as part of their symptom profile. This suggests that maintaining balanced hormone levels is crucial for overall well-being, including headache management.

Adhering to a consistent TRT schedule is essential. A missed dose of testosterone injection can lead to fluctuating hormone levels, potentially triggering headaches. This highlights the importance of regular injections to maintain stable testosterone levels and minimize side effects.

On the flip side, another important consideration is whether excess testosterone could contribute to headaches. While the primary focus is often on low T, can men have too much testosterone? Yes, and elevated levels might lead to various side effects, including headaches. Therefore, maintaining optimal testosterone levels is key.


So, while TRT offers significant benefits for men with low T, it’s essential to consider the potential side effects. Whether dealing with a low testosterone headache or you think you’re getting headaches from testosterone injections, working closely with a healthcare provider can help manage these symptoms. By understanding the intricate relationship between testosterone and headaches, patients can make informed decisions about their treatment options.

For now, staying informed and proactive about one’s health is the best strategy for those navigating the complexities of testosterone therapy and its effects.

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